In other matches, Lucas Bergvall will be absent for Tottenham's game against Manchester United due to concussion protocols, and Viktor Gyokeres will miss Arsenal's visit to Sunderland with a hamstring injury.
Here's a breakdown of the players who are out or doubtful for this weekend's fixtures:
Lucas Bergvall (Tottenham) - concussion
Yves Bissouma (Tottenham) - ankle injury
Ben Davies (Tottenham) - muscle injury
Robert Dragusin (Tottenham) - knee injury
Ademola Lookman (Tottenham) - calf injury
Davide Frattesi (Tottenham) - knee injury
James Maddison (Tottenham) - knee injury
Marcus Edwards (Tottenham) - knee injury
Manchester United
Lee Grant (Manchester United) - knee injury
DOUBTFUL
Mohammed Kudus (Manchester United) - knock
WON'T PLAY
Everton
Jonjoe Kenny (Everton) - thigh injury
Nathan Patterson (Everton) - ankle injury
Fulham
Antonee Robinson (Fulham) - knee injury
DOUBTFUL
Ivan Ndiaye (Fulham) - injury
WON'T PLAY
West Ham
Gabriel Osho (West Ham) - thigh injury
Lukasz Fabianski (West Ham) - back injury
Nils Fullkrug (West Ham) - thigh injury
Kostas Mavropanos (West Ham) - injury
Oliver Scarles (West Ham) - shoulder injury
Burnley
Ali Safi (Burnley) - knee injury
Jason Beyer (Burnley) - hamstring injury
Charlie Roberts (Burnley) - groin injury
DOUBTFUL
N/A
WON'T PLAY
Sunderland
Ademir Alese (Sunderland) - shoulder injury
Daniel Cirkin (Sunderland) - wrist injury
Harrison Diarra (Sunderland) - groin injury
Leon Hjelde (Sunderland) - Achilles tendon injury
Riley Mundle (Sunderland) - hamstring injury
Arsenal
Gabriel Jesus (Arsenal) - knee injury
Viktor Gyokeres (Arsenal) - hamstring injury
Kevin De Bruyne (Arsenal) - knee injury
Nicolas Pepe (Arsenal) - knee injury
Marquinhos (Arsenal) - muscle injury
Martin Odegaard (Arsenal) - knee injury
DOUBTFUL
Omar Alderete (Arsenal) - concussion
Kaylen Arrizabalaga (Arsenal) - knock
Mikel Zubimendi (Arsenal) - injury
WON'T PLAY
Chelsea
Benoît Badiashile (Chelsea) - muscle injury
Lucas Colwill (Chelsea) - knee injury
Dominic Essugo (Chelsea) - thigh injury
Ryan Lavia (Chelsea) - thigh injury
Mykhailo Mudryk (Chelsea) - suspended
Christopher Palmer (Chelsea) - groin injury
Wolves
Elliot Agbadou (Wolves) - red card
Lawrence Chiwome (Wolves) - knee injury
Matt Doherty (Wolves) - knee injury
Rui Gomes (Wolves) - groin injury
DOUBTFUL
Pedro Neto (Wolves) - injury
WON'T PLAY
Aston Villa
Tyrick Mings (Aston Villa) - hamstring injury
Yannick Tielemans (Aston Villa) - calf injury
Bournemouth
N/A
DOUBTFUL
Taylor Adams (Bournemouth) - injury
Alexis Mac Allister (Bournemouth) - calf injury
WON'T PLAY
Brentford
Jesper Tengstedt (Brentford) - knee injury
Arthur Milambo (Brentford) - knee injury
Newcastle
Harrison Ashby (Newcastle) - thigh injury
Alexander Isak (Newcastle) - muscle injury
Victor Livramento (Newcastle) - knee injury
Will Osula (Newcastle) - ankle injury
Wissam Ben Yedder (Newcastle) - knee injury
DOUBTFUL
Bruno Guimaraes (Newcastle) - calf injury
WON'T PLAY
Crystal Palace
Riccardo Cardines (Crystal Palace) - groin injury
Cyril Doucoure (Crystal Palace) - knee injury
Charles Kporha (Crystal Palace) - back injury
Eddie Nketiah (Crystal Palace) - thigh injury
Brighton
Benjamin Gruda (Brighton) - knee injury
Jay Hinshelwood (Brighton) - ankle injury
Steven March (Brighton) - knee injury
James Milner (Brighton) - muscle injury
Adam Webster (Brighton) - knee injury
DOUBTFUL
Riad Caidi (Brighton) - knee injury
Kaoru Mitoma (Brighton) - ankle injury
WON'T PLAY
Nottingham Forest
Ola Aina (Nottingham Forest) - hamstring injury
Dominic Bakwa (Nottingham Forest) - injury
Douglas Luiz (Nottingham Forest) - thig
